A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf
.
From DNA sequence to transcriptional behaviour: a quantitative approach
2009
Nature reviews genetics
| Complex transcriptional behaviours are encoded in the DNA sequences of gene regulatory regions. Advances in our understanding of these behaviours have been recently gained through quantitative models that describe how molecules such as transcription factors and nucleosomes interact with genomic sequences. An emerging view is that every regulatory sequence is associated with a unique binding affinity landscape for each molecule and, consequently, with a unique set of molecule-binding
doi:10.1038/nrg2591
pmid:19506578
pmcid:PMC2719885
fatcat:pyaaq7m7szg4bifbevn44bjmty