Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Jun Yang, Qinqing Li
2020 Frontiers in Neurology  
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn2+. Mn2+ is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels. Mn2+ can be transported along the axons of neurons via microtubule-based fast axonal transport. Based on these properties, MEMRI is used to describe neuroanatomical structures, monitor neural activity, and evaluate axonal transport rates. The application of MEMRI in preclinical animal models of
more » ... nervous system (CNS) diseases can provide more information for the study of disease mechanisms. In this article, we provide a brief review of MEMRI use in CNS diseases ranging from neurodegenerative diseases to brain injury and spinal cord injury.
doi:10.3389/fneur.2020.00143 pmid:32161572 pmcid:PMC7052353 fatcat:hypuo4utcfhufdmqi5ovdhhs5y