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High incidence and mortality rate for ovarian cancer patients, short-term survival until relapse, repeated following surgeries and chemo- therapy, and also low survival rates make the problem of treatment of this pathology vital. Nowadays combination of platinum and paclitaxel (gemcitabine) in addition with targeted therapy (bevacizumab) is the most effective chemotherapy for first and second line of stages III and IV ovarians cancer. Considering high efficacy of these combinations aimed at thedoi:10.17650/1994-4098-2014-0-2-68-72 doaj:6d3dd22f6e0d4c05996d5372c144eff3 fatcat:3dkybmcvezbpxdv2yvkojzke3a