Factors Associated with Achieving Hematological Response in CML (Chronic Myeloid Leukemia) Patient
Indian Journal of Public Health Research & Development
The goal of CML therapy is to achieve complete hematological response first, then cytogenetic response andcomplete molecular response at the very end. Achieving a complete hematological response is the easiest and relatively inexpensive to detect. Several factors are thought to have an association with achieving hematological response. This study sought to determine the factors associated with achieving hematological response in CML patients Method: We conducted an observational retrospective
... nal retrospective cohort study of CML patients at Wahidin Sudirohusodo Hospital and its network on 2018-2019 period. Diagnosis was done by positive BMP (Bone Marrow Punctie) results for CML, then a monthly blood check until a hematological response was achieved. Results: There wer 39 research subjects, 19 male (48.7%) and 20 female (51.3%). No association found between age, gender and achievement of hematological response. Type of therapy was significantly correlated with the achievement of hematological response, with the highest number found in Nilotinib therapy compared to other group. (54,1%; p = 0.046) Subjects who achieve hematological response had a lower percentage of blast cells. (6.1% vs. 7.9% ; p = 0.016) Conclusion: The use of Nilotinib therapy was significantly associated with a succesful achievement of hematological response. A lower percentage of blast cells was found in CML patients who achieved hematological response.