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Emerging clues for regenerative medicine in infertility: an overview for cell sources and results with a sensitizing modifier PRMT5
AME Medical Journal
Germ cells are the most important cell type for generation continuation in all sexually reproductive species. Pluripotent stem cells (PSCs) are important cell resources for disease modeling and tissue-specific differentiation in regenerative medicine. Ground-state naïve PSCs share similar transcriptional and epigenetic features with primordial germ cells (PGCs) and PGC like cells can be derived from PSCs in mice. As a critical regulator in PSCs and PGCs, PRMT5 has a versatile role in regulatingdoi:10.21037/amj.2017.05.16 fatcat:amildshzxrgntmkwctlqqujxce