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Abbreviations used: dSTORM, direct stochastic optical reconstruction microscopy; MAL, myelin and lymphocyte; Syt7, synaptotagmin-7; TIRF, total internal reflection fluorescence. M.-I. Thoulouze and A. Alcover contributed equally to this paper. How the vesicular traffic of signaling molecules contributes to T cell receptor (TCR) signal transduction at the immunological synapse remains poorly understood. In this study, we show that the protein tyrosine kinase Lck, the TCR subunit, and thedoi:10.1085/jgp.1425oia44 fatcat:gqh5zqi2orhybdjji3vzixa27m