The prevalence of Vitamin D deficiency in pregnancy and neonatal outcomes

Dr. Susheela Gayam, Head of Department, Department of Obstetrics and Gynaecology Vijay Marie Hospital and Educational Society, Khairatabad, Hyderabad, Telangana, India, Dr. Summaya Fatima, Dr. Neelima C, Dr. Geeta Rani, Registrar, Department of Obstetrics and Gynaecology Vijay Marie Hospital and Educational Society, Khairatabad, Hyderabad, Telangana, India, Senior Consultant, Department of Obstetrics and Gynaecology Vijay Marie Hospital and Educational Society, Khairatabad, Hyderabad, Telangana, India, Junior Consultant, Department of Obstetrics and Gynaecology Vijay Marie Hospital and Educational Society, Khairatabad, Hyderabad, Telangana, India
2020 Obsgyne Review: Journal of Obstetric and Gynecology  
Vitamin D is an essential fat-soluble vitamin and has multiple functions. It affects calcium metabolism, modulates the immune system, cell proliferation, and differentiation. Objective: To study the prevalence of vitamin D deficiency in pregnant women and neonatal outcome in a tertiary care hospital, to study the association between maternal vitamin D and medical disorders, and to correlate maternal vitamin D deficiency with neonatal vitamin D levels and neonatal outcomes. Materials and
more » ... terials and Methods: This cross-sectional and observational study was conducted over a period of one year on 355 antenatal women admitted for safe confinement. 4 ML of whole blood was collected from median ante-cubital fossa and vitamin D levels were assessed using ELFA [Enzyme Linked Fluorescent Assay] following delivery, and 2ml of cord blood was also collected and sent for Vitamin D levels. Results: Out of the total study population, 12.96% (46) had adequate levels of vitamin D, the majority -74.65% (265) had insufficient vitamin D levels, and 12.39% (44) had severe vitamin D deficiency. The overall deficiency among neonates was 95.22%. No significant association was found between vitamin D deficiency and maternal complications, except for the mode of delivery which was statistically significant with a P-value of 0.04. Conclusion: This study reaffirms that vitamin D deficiency is on the increase and therefore needs intervention by biochemical screening and corrective measures during pregnancy.
doi:10.17511/joog.2020.i04.03 fatcat:tmxoibmfqfdt5i2uk6rw5pltlu