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Because of high heterogeneity and invasiveness, treatment of GlioBlastoma Multiform (GBM) still remains a complex challenge. Several recent advanced therapies have improved precision of treatment deliverance. Multimodality imaging plays an increasingly important role in this process and images segmentation has become an essential part of the pipeline of standard treatment planning system. With the sophistication of multimodality information, the development of reliable and robust segmentationdoi:10.1016/j.irbm.2015.12.004 fatcat:ttxhydw3vnew7gvuga3uwb2dly