The effects of entomopathogen fungus isolates on the mortality of Spodoptera littoralis (Boisduval) (Lepidoptera: Noctuidae) larvae were increased and accelerated when co-administered with eicosanoid inhibitors (EBIs) (Dexamethasone, Indomethacin, Esculetin Phenidone Ibuprofen and Naproxen). The mode of action of these compounds are different. When eicosanoid inhibitors were applied to S. littoralis larvae together with entomopathogenic fungus isolates (Beauveria 6646 and Metarhizium 3293),

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... accelerated deaths of the insect and consequently increased mortality rates. In addition, when different doses of Phenidone, one of the eicosanoid inhibitors, were administered to the larvae with the fungal isolates, there was a significant increase in mortality due to the dose of Phenidone. These results showed that the application of eicosanoid inhibitors with fungal agents to S. littoralis larvae increased the effectiveness of these potential microbial control agents.