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Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells
AbstractInactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing mutations at one (1M), two (2M), or three (3M) antigenic sites, in addition to a virus containing the 1M mutation and a substitution of the Ca2 antigenic site (Sub) with one derived from an H5 hemagglutinin (HA) to challenge mice of both sexes.doi:10.1101/2022.05.31.494237 fatcat:gxfpqkt7hzdk5jaajx5237myy4