Targeting the Molecular & Cellular Pillars of Human Aging with Exercise

Jorming Goh, Esther Wong, Janjira Soh, Andrea Maier, Brian Kennedy
2021
Biological aging is the main driver of age-associated chronic diseases. In 2014, the United States National Institute of Aging (NIA) sponsored a meeting between several investigators in the field of aging biology, who identified 7 biological pillars of aging and a consensus review, "Geroscience: Linking Aging to Chronic Disease," was published. The pillars of aging demonstrated the conservation of aging pathways in diverse model organisms and thus, represent a useful framework with which to
more » ... y human aging. In this present review, we revisit the 7 pillars of aging from the perspective of exercise and discuss how regular physical exercise can modulate these pillars to stave off age-related chronic diseases and maintain functional capacity.
doi:10.1111/febs.16337 pmid:34968001 fatcat:gc6raxra4jh3rpc3kdigl37w5i