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There are endocrine and immunological changes that occur during onset and progression of the overweight and obese states. The inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKε) was originally described as an inducible protein kinase; whole-body gene deletion or systemic pharmaceutical targeting of this kinase improved insulin sensitivity and glucose tolerance in mice. To investigate the primary sites of action associated with IKKε during weight gain, we describe the first mousedoi:10.1152/ajpendo.00309.2019 pmid:31661298 fatcat:f667qw7ur5htdpksqd5ouz4ns4