Corrective 111 In Capromab Pendetide SPECT Image Reconstruction Methods for Improved Detection of Recurrent Prostate Cancer [report]

Benjamin M. Tsui
2006 unpublished
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more » ... torate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. particularly with regard to pelvic SPECT studies used to detect possible disease in the prostate fossa and pelvic lymph node (LN). The hypothesis of this proposal is that the superior spatial resolution, high image contrast, and much reduced image artifacts that result from the corrective SPECT image reconstruction methods would substantially aid in the detection and diagnosis of prostate cancer. To test our hypothesis, we propose five specific aims: (1) to develop simulation tools and methods that allow efficient generation of accurate 111In PS projection data from the human pelvic area, (2) to study the effects of 3D image degrading factors on 111In PS SPECT images, (3) to develop 3D corrective image reconstruction methods for 111In PS SPECT that provide much improved image quality and quantitative accuracy by incorporating models of the 3D image degrading factors, (4) to evaluate the 3D corrective image reconstruction methods for clinical 111In PS SPECT studies using simulated patient data, and Hotelling and human observer studies, and (5) to evaluate the clinical efficacy of the corrective image reconstruction methods as applied to 111In PS SPECT using patient data. SUBJECT TERMS
doi:10.21236/ada462023 fatcat:6add7xtylndqpjpxragsrceufi