COMPARISON OF EFFICACY OF INTRAVENOUS PARACETAMOL AND INTRAVENOUS DICLOFENAC FOR POST-OPERATIVE ANALGESIA IN LAPAROSCOPIC SURGERIES
Journal of Evidence Based Medicine and Healthcare
BACKGROUND This was a double blind, prospective randomized clinical study. 105 patients scheduled to undergo elective laparoscopic surgery in a tertiary hospital between Jan 2014 to Aug 2015 were randomly selected by closed envelope method after obtaining the institute's ethical committee approval. METHODS One hundred and five patients belonging to ASA-PS I & II, scheduled for elective laparoscopic surgery were included. The patients were randomly allocated to one of the three groups to receive
... one gram/100 ml IV paracetamol (group A), 75 mg of IV diclofenac in 100 ml saline (group B) and 100 ml of normal saline (group C) over 20 min before the completion of the skin closure. Analgesia was assessed postoperatively. VAS score was used to assess the efficacy of analgesia. RESULTS We found that HR was comparable between paracetamol and diclofenac. SBP, DBP and MAP were low in diclofenac group till the patient was given rescue analgesia which was statistically significant. The duration of analgesia was 317.14±55.549 min with paracetamol and 297.43±65.311 min with diclofenac which was comparable. There were no serious side effects noted with any of the groups. CONCLUSIONS Paracetamol appears to be equally safe and effective analgesic for postoperative pain like diclofenac. It is haemodynamically stable and does not cause respiratory depression. Paracetamol is devoid of any serious side effects and can be used for both intra and postoperative analgesia.