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The predictable 3D structure of double-stranded DNA renders it ideally suited as a template for the bottomup design of functionalized nucleic acid-based active sites. We here explore the use of a 14mer DNA duplex as a scaffold for the precise and predictable positioning of catalytic functionalities. Given the ubiquitous participation of the histidine-based imidazole group in protein recognition and catalysis events, single histidine-like modified duplexes were investigated. Tethering histaminedoi:10.1093/nar/gku1306 pmid:25520197 pmcid:PMC4288195 fatcat:ws4mppz7k5drxgux4zw6sbstsa