This work is about the role of melatonin in development age-related pathologyoncologic and neurodegenerative diseases. The metabolite of melatonin 6-sylfateoxymelatonin (6-COMT) is highinformative noninvasive biological marker in diagnosis, predicting and estimation of treatment effect of oncology and neurodegenerative disease in eldery and old age. The alteration of excretion of 6-COMT was verified at patients with intestine, lung, larynx, prostate, uterus and mammary gland. We found the

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... ation between the level of expression of 6-COMT and the step of histological differentiation of tumor. The correlation between the expression of β-amiloid, τ-protein, Bcl-x and melatonin at people with Alzheimer disease demonstrated it's significant in the development of neurodegenerative processes.