SP544EFFECTS OF NEBIVOLOL AND IRBESARTAN ON AMBULATORY BLOOD PRESSURE IN HEMODIALYSIS PATIENTS WITH INTRADIALYTIC HYPERTENSION: PRELIMINARY RESULTS FROM A RANDOMIZED CROSS-OVER STUDY

Athanasios Bikos, Loutradis Charalampos, Antonios Karpetas, Vasilios Raptis, Alexia Piperidou, Rigas Kalaitzidis, Evdoxia Ginikopoulou, Stylianos Panagoutsos, Ploumis Pasadakis, Ilias Balaskas, Aikaterini Papagianni, Vasilios Liakopoulos (+1 others)
2017 Nephrology, Dialysis and Transplantation  
INHD= -14.75g [CI: -29.62-0.12], CHD= 6.54 g [CI: -7.48-20.57], P=0.02), with a significant improvement in LV mass/LV end-diastolic volume in the INHD group compared to CD group (mean difference; INHD= -0.07g/ml [CI: -0.15-0], CHD= 0.06g/ml [CI: -0.01-0.13], P=0.01), and no change in LV end-diastolic volume. There was a significant reduction in global native T1 in the INHD group compared to the CD group (mean difference; INHD= -30.62ms [95% CI: -56.49, 4.75], CHD=0.4ms [95% CI: -25.47, 26.27],
more » ... =0.05) and non-septal native T1 values (mean difference; INHD= -30.93ms [95% CI: -58.44, -3.41], CHD=8.96ms [95% CI: -18.56, 36.47], P=0.02). There were non-significant improvements in ejection fraction, GLS, GCS and aPWV in the INHD group compared to the CD group. Reduction in LV Mass correlated significantly with reduction in native T1 ((r=0.526, P=0.03). CONCLUSIONS: A six-month program of extended hours INHD was associated with a reduction in LV mass and favourable LV remodelling. The reduction in native T1 mapping in INHD patients suggest a reduction in myocardial fibrosis compared to control patients who remained on thrice weekly, 4-hour HD. These data merit testing in future larger trials of INHD.
doi:10.1093/ndt/gfx152.sp544 fatcat:3iqcdnf365afnlpgtpznpk6ona