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Cardiac status after long-term growth hormone replacement therapy in adult growth hormone deficient patients. A single centre audit based on echocardiographic investigations before and during GH replacement therapy
Growth hormone (GH) is known as a hormone involved in regulation and influence of somatic growth but also of a long variety of metabolic pathways. GH exerts its effect in the body directly and indirectly, by stimulating insulin like growth factor-1 (IGF-1) production. Both GH and IGF-1 receptors are expressed in cardiac myocytes. GH deficiency may develop deformities of cardiac structure as well as impaired systolic and diastolic functions. Further, earlier investigations indicate that IGF-1 excess has an hypertrophic effect on cardiac cells.doi:10.1530/endoabs.41.gp58 fatcat:374pmlo2wja5lgm5dtbj3nf654