Cardiac status after long-term growth hormone replacement therapy in adult growth hormone deficient patients. A single centre audit based on echocardiographic investigations before and during GH replacement therapy

Sissela Skoglund, Ulla Feldt Rasmussen, Marianne Klose, Christian Hassager
2016 Endocrine Abstracts  
Growth hormone (GH) is known as a hormone involved in regulation and influence of somatic growth but also of a long variety of metabolic pathways. GH exerts its effect in the body directly and indirectly, by stimulating insulin like growth factor-1 (IGF-1) production. Both GH and IGF-1 receptors are expressed in cardiac myocytes. GH deficiency may develop deformities of cardiac structure as well as impaired systolic and diastolic functions. Further, earlier investigations indicate that IGF-1 excess has an hypertrophic effect on cardiac cells.
doi:10.1530/endoabs.41.gp58 fatcat:374pmlo2wja5lgm5dtbj3nf654