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Further Evidence for the Role of Glucose as a Metabolic Regulator of Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator Activity in Goats
2004
Endocrinology
The present study examined the relative importance of blood glucose vs. free fatty acids as a metabolic signal regulating GnRH release as measured electrophysiologically by multiple-unit activity (MUA) in the arcuate nucleus/median eminence region in ovariectomized, estradiol-treated goats. MUA was recorded before, during, and after 1) 5 cellular glucoprivation by peripheral infusion of 2-deoxy-D-glucose (2DG; 25, 50, and 75 mg/kg/h, iv), 2) peripheral hypoglycemia in response to various doses
doi:10.1210/en.2003-1516
pmid:15044379
fatcat:jn5sob4cjrdmzodu4raehwsowq