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Enhancement of Electrical Stability of Acutely Ischemic Myocardium by Edrophonium
Recently we demonstrated that vagal stimulation increases ventricular fibrillation threshold (VFT) and decreases the incidence of spontaneous ventricular fibrillation during acute coronary occlusion. Assuming this protective effect of the vagus to be mediated through acetylcholine release, we hypothesized that inhibition of acetylcholinesterase, a potential clinical intervention, would also enhance electrical stability of acutely ischemic myocardium. A balloon cuff was placed around the leftdoi:10.1161/01.cir.50.1.99 pmid:4835255 fatcat:hkwbuvo6tffrjjb5ztjj2n6xpq