Purpose The hemostatic effect of Tranexamic Acid (TXA) is analyzed in total hip total hip arthroplasty (THA) operated on chronic kidney disease (CKD) patients in Zhuang nationality. Methods A review of 53 Zhuang nationality patients with CKD who underwent unilateral total hip replacement at the People's Hospital of Guangxi Zhuang Autonomous Region from December 2012 to December 2019. They were divided into two groups: 28 patients in the TXA group and 25 patients in the non-TXA group. Nine

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... s of comparison are operation time, blood loss during operation, postoperative drainage, changes of hemoglobin content before and after operation, prothrombin time before and after operation, recessive blood loss during operation, the number of patients with blood transfusion and that of thrombosis one month after operation. Results Two groups of CKD patients Compared, there was no statistically significant difference (p> 0.05) in the following aspects, namely, preoperative hemoglobin, preoperative and postoperative prothrombin time, preoperative and postoperative creatinine, preoperative and postoperative blood urea nitroge, while in the aspects of immediate postoperative hemoglobin, 24-hour postoperative hemoglobin, intraoperative bleeding, postoperative drainage and 24-hour occult blood loss, the number of patients with blood transfusion (4 in TXA group and 10 in non-TXA group), there was statistically significant difference (p< 0.05). Deep venous thrombosis of lower extremities was found in both groups of CKD patients after one month. No cases of complications or death were reported in the included patients. Conclusions In the THA, the use of TXA on CKD patients in Zhuang nationality can reduce dominant and recessive blood loss and decrease the incidence of lower extremity deep vein embolism.