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Journal of Synthetic Organic Chemistry, Japan
P-1's) which recognize and/or cleave DNA were designed and synthesized. 2-Aminodipyrido [1,2-a : 3', 2' -d] imidazoles (Glu-P's) which are potent muta-carcinogens isolated from a pyrolysate of L-glutamic acid were used as intercalator moieties. Bis-intercalators possess extremely high affinity toward double stranded DNA and stabilize the double helix structure of DNA from heat denaturation effectively. Hemin-Glu-P-l's cleaved DNA at G-C and G-T sequences preferentially. Glu-P-1 moiety whichdoi:10.5059/yukigoseikyokaishi.43.908 fatcat:6nnssbyz4neztjpm5pgbp7toxm