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Cell-Specific Computational Modeling of the PIM Pathway in Acute Myeloid Leukemia
2016
Cancer Research
Personalized therapy is a major goal of modern oncology, as patient responses vary greatly even within a histologically defined cancer subtype. This is especially true in acute myeloid leukemia (AML), which exhibits striking heterogeneity in molecular segmentation. When calibrated to cell-specific data, executable network models can reveal subtle differences in signaling that help explain differences in drug response. Furthermore, they can suggest drug combinations to increase efficacy and
doi:10.1158/0008-5472.can-16-1578
pmid:27965317
fatcat:j7da354itzceflj4fiebzdpeyi