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Controlled Drug Release Asymptotics
1998
SIAM Journal on Applied Mathematics
The solution of Higushi's model for controlled release of drugs is examined when the solubility of the drug in the polymer matrix is a prescribed function of time. A time-dependent solubility results either from an external control or from a change in pH due to the activation of pH immobilized enzymes. The model is described as a one-phase moving boundary problem which cannot be solved exactly. We consider two limits of our problem. The first limit considers a solubility much smaller than the
doi:10.1137/s0036139995293269
fatcat:5vbr6l4zmzbm5pbzd4h474thzm