Platelet aggregates, a marker of severe COVID-19 disease

Alexandros Rampotas, Sue Pavord
2020 Journal of Clinical Pathology  
Thrombocytopenia is common in an intensive care unit (ICU) setting due to endogenous and iatrogenic factors. Despite that, thrombocytopenia in patients with severe COVID-19 infections is surprisingly uncommon. By examining the blood film of 20 ICU patients with COVID-19, we observed the presence of platelet aggregates and macrothrombocytes indicating increased platelet activity. We compared these findings with 20 blood films of non-severe COVID-19 cases where these findings were absent. These
more » ... ere absent. These morphology features could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when COVID-19 manifests with thrombotic complications or respiratory failure.
doi:10.1136/jclinpath-2020-206933 pmid:33067181 fatcat:b7d3643vybg3za56mry4ppvtby