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Alterations of functional circuitry in aging brain and the impact of mutated APP expression
2018
Neurobiology of Aging
Alzheimer's disease (AD) is a disease of aging that results in cognitive impairment, dementia and death. Pathognomonic features of AD are amyloid plaques composed of proteolytic fragments of the amyloid precursor protein (APP) and neurofibrillary tangles composed of hyperphosphorylated tau protein. One type of familial Alzheimer's disease (FAD) occurs when mutant forms of APP are inherited. Both APP and tau are components of the microtubule-based axonal transport system, which prompts the
doi:10.1016/j.neurobiolaging.2018.06.018
pmid:30055413
pmcid:PMC6159914
fatcat:rkj5jkpwjne7zp3m5do5zcarca