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Dynamics of anteroposterior axis establishment in a mammalian embryo-like system
[article]
2021
bioRxiv
pre-print
In the mammalian embryo, specification of the anteroposterior (AP) axis demarcates one of the first steps of body plan formation. While this process requires interactions with extra-embryonic tissues in the native embryo, minimal in vitro systems from embryonic stem cells (ESCs) undergo initial AP polarization in the absence of any localized, external cues. This self-organizing potential of stem cells remains not well understood. Here, we study such an initial symmetry breaking event in
doi:10.1101/2021.02.24.432766
fatcat:sg3d3yal4ffi5f2vks4k3eg5km