Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity

Junjiang Chen, Lianqun Cui, Jingliang Yuan, Songcun Zhang, Rongmei Ma, Hongjun Sang, Qingjiang Liu, Lianfeng Shan
2017 Molecular Medicine Reports  
The present study aimed to investigate whether diminazene attenuates myocardial infarction (MI) in rats. In addition, the present study investigated whether ACE2 signaling was involved in the effects of diminazene on protein function. A rat model of acute myocardial infarction (AMI) was established by occlusion of the left anterior descending coronary artery. The AMI model rats received intraperitoneal injections of diminazene (5 mg/kg/day) for 3 days. Treatment with diminazene significantly
more » ... ibited the expression of casein kinase and lactate dehydrogenase, and reduced infarct size in AMI rats. The findings indicated that diminazene significantly reduced the levels of inflammatory factors including tumor necrosis factor-α and interleukin-6, suppressed the protein expression of cytochrome c oxidase subunit 2 (COX-2) and inducible nitric oxide synthase (iNOS), and activated angiotensin-converting enzyme 2 (ACE2), angiotensin II receptor type 1 (AT1R) and MAS1 proto-oncogene, G protein-coupled receptor (MasR) protein expression in AMI model rats. In conclusion, the present study demonstrated that diminazene attenuated AMI in rats via suppression of inflammation, reduction of COX-2 and iNOS expression, and activation of the ACE2/AT1R/MasR signaling pathway.
doi:10.3892/mmr.2017.7152 pmid:28791381 fatcat:yb6uo77tefdflevzjxf4tzm4fq