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The WD40 Domain of HIRA Is Essential for RI-nucleosome Assembly in Xenopus Egg Extracts
2017
Cell Structure and Function
Histone chaperones are a group of histone-binding proteins that facilitate the assembly of nucleosomes, the fundamental structural units of chromatin in eukaryotes. In nucleosome assembly, deposition of a histone H3-H4 tetramer onto DNA is the first and critical step, which is mediated by the histone chaperones HIRA and CAF-1. HIRA and CAF-1 are reportedly involved in DNA replication independent (RI) and replication coupled nucleosome assembly, respectively. However, the mechanisms by which
doi:10.1247/csf.17001
pmid:28381790
fatcat:jxo4lukk4nhvhaq3dxmesww2ua