Some studies have shown that aerobic exercise could promote the antioxidant defense system. Therefore, the aim of present study was to investigate the effects of aerobic and single bout of exhaustive exercise on salivary and serum malondialdehyde (MDA) and total antioxidant capacity (TAC) in non-athlete males. Materials and Methods: Twenty-seven male (age: 18-21 year) were randomly assigned into Control (n=12) and Aerobic-training (n=15) groups. Training group was participated in an aerobic

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... cise program (50-70% of Heart Rate Reserve) for 8 weeks (three times per week). After the termination of exercise program, both groups performed a progressive exercise to exhaustion on treadmill. To evaluate the MDA and TAC, serum and salivary samples were collected before and after the training as well as after the exhaustive exercise. Results: Aerobic exercise caused a significant increase in salivary and serum TAC (P<0.05). Moreover, the intensive exercise reduced the serum TAC in Control group (P<0.05). After the termination of exercise program, serum MDA was lower in Training group than the Control one, while no difference was noted for salivary measurement. A significant rise in serum MDA was found in Control group after the exhaustive exercise (P<0.05). However, there was no significant relationship between the salivary and serum TAC and MDA levels. Conclusion: Aerobic exercise could be effective in preventing the exhaustive exercise-induced lipid peroxidation. Although the interpretation of results on salivary parameters require further studies.