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Purpose: Hypophysectomy is a method used in analgesia in patients with painful bone metastases. The pain relief after this procedure is not pathophysiologically fully understood. In only a few studies Leksell gamma knife (LGK) was used for radiosurgical hypophysectomy. In our study, we performed the LGK hypophysectomy in patients with intractable cancer-related pain due to bone metastases and evaluated the impact of this method on pain relief.Methods: From 1994 to 2020 we enrolled 20 patientsdoi:10.21203/rs.3.rs-1626044/v1 fatcat:lwslnvbl65aeni7ww2uhqyqs24