Analgesic, Antidiarrheal and Antidepressant Activities of Anethum sowa Linn. in Swiss-Albino Mice Model

Muhammad Abdullah Al Mansur, M Mahboob Ali Siddiqi, Koushik Saha
2018 Bangladesh Pharmaceutical Journal  
<p>The hexane (HE), dichloromethane (DCME), ethyl acetate (EAE) and methanol (ME) extracts of seed and stem of Anethum sowa were subjected to screenings for analgesic, anti-diarrheal and anti-depressant activities. The peripheral and central analgesic actions were determined by using formalin-induced writhing test and tail immersion method. The DCME extract of stem, at a dose of 200 mg/kg body weight, significantly reduced the number of writhing movements whereas the methanol extract of seed at
more » ... the same dose exhibited remarkable analgesic activity in tail immersion method. In castor oil induced anti-diarrheal assay, the ethyl acetate extract of stem, at 400 mg/kg body weight, exhibited significant anti-diarrheal effect. In addition, significant anti-depressant activity was observed at a dose of 400 mg/kg body weight as compared to the standard drug in case of HE extract of stem.</p><p>Bangladesh Pharmaceutical Journal <strong>21</strong>(1): 1-6, 2018</p>
doi:10.3329/bpj.v21i1.37899 fatcat:w6jfnlpgxffhtohjabqaetqgle