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Glutamate decarboxylase (L-glutamate-1-carboxylase, GAD; EC 188.8.131.52) is a pyridoxal 5-phosphate-dependent enzyme, which catalyzes the irreversible α-decarboxylation of L-glutamic acid to γ-aminobutyric acid (GABA) and CO2. The enzyme is widely distributed in eukaryotes as well as prokaryotes, where it – together with its reaction product GABA - fulfils very different physiological functions. The occurrence of gad genes encoding GAD has been shown for many microorganisms, anddoi:10.20944/preprints202010.0538.v1 fatcat:kyzxkgnz5rcfnjwuxiqttwj2su