Learning pair-wise gene functional similarity by multiplex gene expression maps

Li An, Haibin Ling, Zoran Obradovic, Desmond J Smith, Vasileios Megalooikonomou
2012 BMC Bioinformatics  
The relationships between the gene functional similarity and gene expression profile, and between gene function annotation and gene sequence have been studied extensively. However, not much work has considered the connection between gene functions and location of a gene's expression in the mammalian tissues. On the other hand, although unsupervised learning methods have been commonly used in functional genomics, supervised learning cannot be directly applied to a set of normal genes without having a target (class) attribute.
doi:10.1186/1471-2105-13-s3-s1 pmid:22536893 pmcid:PMC3375633 fatcat:r3owbohgo5hhpnk2njkat6lwj4