MRI Brain Templates of the Male Yucatan Minipig [article]

Carly Norris, Jonathan Lisinski, Elizabeth Fievisohn, John W. VanMeter, Pam VandeVord, Stephen M LaConte
2020 biorxiv/medrxiv   pre-print
The pig is growing in popularity as an experimental animal because its gyrencephalic brain is similar to humans. Currently however, there is a lac of appropriate brain templates to support functional and structural neuroimaging pipelines. The primary contribution of this work is an averag volume from an iterative, non-linear registration of 70 male Yucatan minipig subjects whose ages ranged from five to seven months. In addition, several aspects of this study are unique, including the
more » ... uding the comparison of linear and non-linear template generation, the characterization of a large and homogeneous cohort, an analysis of effective resolution after averaging, and the evaluation of potential within template bias as well as a comparison with a template from another minipig species using a "left-out" validation set. We found that within our highly homogeneous cohort, non-linear registration produced better templates, but only marginally so. Although our T1-weighted data were resolution limited, we preserved effective resolution across the multi-subject average, produced templates that have high gray-white matter contrast, and demonstrated superior registration accuracy compared to the only known alternative minipig template.
doi:10.1101/2020.07.17.209064 fatcat:xroyc7fzmjep3muwyub5uylx5y