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Aberrant methylation and silencing of IRF8 expression in non-small cell lung cancer
2014
Oncology Letters
The aim of the present study was to investigate the aberrant methylation and altered expression of the interferon regulatory factor 8 (IRF8) gene in non-small cell lung cancer (NSCLC). Pyrosequencing assays were performed on 191 tumor specimens from NSCLC patients. The changes in IRF8 mRNA expression, prior to and following treatment with a demethylating agent and methylation itself, were examined in 13 lung cancer cell lines by quantitative polymerase chain reaction (qPCR) and pyrosequencing.
doi:10.3892/ol.2014.2234
pmid:25120651
pmcid:PMC4114630
fatcat:y77nidkglrcufder3xom33qkbi