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Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature—A New Goal for Early Diagnosis and Therapy?

Filippo Ricciardiello, Michela Falco, Giuseppe Tortoriello, Ferdinando Riccardi, Raul Pellini, Brigida Iorio, Giuseppe Russo, Giuseppe Longo, Ciro Coppola, Takashi Takeuchi, Anna Grimaldi, Marianna Abate (+10 others)
2021 Journal of Clinical Medicine  

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Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous malignancies presenting a wide range of pathological and clinical manifestations. Herein, we retrospectively characterize ten patients diagnosticated with LNEC, five of which were defined as well-moderately differentiated neuroendocrine carcinomas, and five that were defined as poorly differentiated neuroendocrine carcinomas, according to the latest WHO classification. Clinical features were analyzed and compared
more » ... en the two subgroups together with a microRNA study which evidenced a peculiar signature likely related to poorly differentiated larynx neuroendocrine carcinomas. These findings may offer new useful insights for clinicians to improve diagnosis efficiency, therapy response, and patients' outcome for this aggressive neoplasm.
doi:10.3390/jcm10092019 pmid:34066893 fatcat:o6gvxea6yfgzjn2jk2lahnd5bi
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Filippo Ricciardiello, Michela Falco, Giuseppe Tortoriello, Ferdinando Riccardi, Raul Pellini, Brigida Iorio, Giuseppe Russo, Giuseppe Longo, Ciro Coppola, Takashi Takeuchi, Anna Grimaldi, Marianna Abate, Marianna Scrima, Alessia Maria Cossu, Raffaele Addeo, Alessandro Ottaiano, Alfonso Scarpa, Amedeo Boscaino, Giovanni Motta, Michele Caraglia, Marco Bocchetti, Gabriella Misso. "Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature—A New Goal for Early Diagnosis and Therapy?." Journal of Clinical Medicine 10.9 (2021) 2019