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MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY
2019
Drug development & registration
Preserved Fulltext
Complex clinical and biological study of 115 schizophrenic patients with long-term antipsychotic treatment was carried out. Concentrations of brain-derived neurotrophic factor (BDNF) and prolactin levels in blood serum in schizophrenic patients and healthy subjects were determined to multiplex analyzer MAGPIX (Luminex, USA) using the kits MILLIPLEX® MAP (Merck, Germany). BDNF concentration was significantly correlated with the severity of positive symptoms in schizophrenic patients.
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