Enxerto bovino liofilizado: comportamento histológico após seguimento de 49 meses em seres humanos

Carlos Roberto Galia, Giuseppe De Luca Júnior, Luiz Müller Ávila, Ricardo Rosito, Carlos Alberto Souza Macedo
2012 Revista Brasileira de Ortopedia  
Objective: To analyze the histological behavior of bovine lyophilized grafts (BLG) produced according to a protocol developed by the first author, in humans over a 49-month period by measuring the graft/bone neoformation ratio in relation to the total mineralized area. Methods: This was a case series involving 12 patients: eight females (66%) and four males (34%), totaling 13 biopsies. BLG was used, and surgical reintervention was subsequently required during the period 2000 to 2011. The slides
more » ... produced were stained with hematoxylin-eosin (HE), were analyzed by a pathologist and were digitized for the proposed evaluation. Results: The mean age was 57 years and the mean follow-up was 49 months (range: 6-115). The average proportion of BLG was 42% (range: 13-85) and neoformed bone, 58% (range: 15-87) in relation to the total area mineralized. Conclusions: This study demonstrated that the BLG used presented osteoconductive characteristics and biocompatibility. BLG is a therapeutic option that can be used in orthopedic surgery in which bone defects need to be filled.
doi:10.1590/s0102-36162012000600017 fatcat:5hdrmgcjpbfzlo5yx4whjukdsu