This study aims to analyze the effect of Rupiah (IDR) Exchange Rate, Interest in Transaction, and Interest in Borrowing Capital on MSME Profitability with Inflation as Moderating variable (Case Study on MSMEs in Serang Banten in 2016 – 2020). This study uses quantitative methods, with secondary data in the form of panel data with data collection by Accendental Sampling. 84 MSMEs actors registered in the Banten Indonesian Farmers Cooperative (KPIB) in 2016 – 2020. The data obtained are then

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... ssed with the SPSS Version 23 analysis tool. The analyses used in this study are. Descriptive Statistical Test, Data Normality Test, Multicollinearity Test, Heteroscedasticity Test, Autocorrelation Test, Multiple Regression Analysis Test, Coefficient of Determination Test, t-Test, and Moderating Regression Analysis Test. The results of this study show that the decline in the IDR exchange rate affects the profitability of MSMEs; interest in the transaction does not affect the profitability of MSMEs; interest in capital borrowing affects the profitability of MSMEs; Inflation moderates the effect of the decline in the IDR exchange rate on MSME profitability; Inflation moderates the effect of interest in a transaction on MSME profitability; and Inflation moderates the Effect of Interest in Capital Borrowing on MSME Profitability.**)