Gene Expression Endpoints Following Subchronic Thiamethoxam Exposure in Adult Male Rabbits

Ahmed R. Elsawasany, Alexander A. Deltsov, Osama S. El Okle, Omnia I. El Euony, Sergey V. Pozyabin, Konstantin S. Ostrenko
2022 Annual Research & Review in Biology  
Aim: to investigate the sub chronic toxicity of thiamethoxam on some parameters of reproductive performance in adult male rabbits including gene expression of LDH-C4, FSHβ and LHβ and GnRHR. Method: sixteen adult male Chinchilla rabbits were divided into two equal groups. Animals in the first group were treated orally with TMX at dose of 250 mg/kg body weight for 90 days. The second group was served as control. Result: Obtained results showed that TMX increased the relative weight of some
more » ... uctive organs including testis and prostate. Hormonal analysis revealed that, TMX induced a significant elevation in the serum testosterone level, while the concentrations of FSH and LH hormones did not exhibit any alterations between treated and control groups. In addition, LDH-C4, FSHβ and LHβ and GnRHR genes were down regulated in TMX treated group. Conclusion: Administration of thiamethoxam for 90 days in male rabbits induced a noticeable adverse effect on serum testosterone level and down regulated genes related to male rabbit reproductive performance.
doi:10.9734/arrb/2022/v37i330492 fatcat:4jhpgxztx5g6fil46hcwk5cswu