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Increased Bioactivity of Rat Atrial Extracts: Relation to Aging and Blood Pressure Regulation
The journals of gerontology. Series A, Biological sciences and medical sciences
The purpose of this study was to evaluate the possible role of atrial factor(s) in the regulation of cardiovascular homeostasis and their relationship to aging. Rats were anesthetized and received jugular vein, carotid artery, and bilateral ureteral catheterization. After a half-hour equilibration period, the rats received 0.5 ml of atrial extract with a concentration of proANP (atrial natriuretic peptide) of 150 g/ml prepared from either aged (18-20 month, "aged extract group", n ϭ 12) ordoi:10.1093/gerona/55.8.b390 pmid:10952360 fatcat:etu327igcfcizk575uojfupkeu