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Beyond Pairwise Interactions: Higher-Order Dynamics in Protein Interaction Networks
[article]
2022
bioRxiv
pre-print
AbstractProtein interactions form a complex dynamic system that shapes cell phenotype and function; in this regard, network analysis is a powerful tool for studying the dynamics of cellular processes. Graph-based models are limited, however, in that these models consider only pairwise relationships. Higher-order interactions are well-characterized in biology, including protein complex formation and feedback or feedforward loops. These higher-order relationships are better represented by a
doi:10.1101/2022.05.03.490479
fatcat:ufd6ncgbxnblnh6fmhqlrb7uuq