Volume 21 Number September 2015 Case report IgM ocular cicatricial pemphigoid: a unique insight into the immune system

Noor Tazudeen, Sonoa Au, Jonathan Pewitt, Elmer Tu, Iris Aronson, Iris Aronson
A 42-year-old man with ocular erythema and scarring had a conjunctival biopsy revealing depostion of IgM and C3 without IgG at the epithelial basement membrane zone. Treatment with doxycyline, dapsone, and mycophenolate mofetil was unsuccessful and treatment with rituximab has led to partial remission of the conjunctival inflammation. He has undergone 4 cycles of rituximab treatment at intervals of 12 to 18 months.