Active delineation of Meyer's loop using oriented priors through MAGNEtic tractography (MAGNET)

Maxime Chamberland, Benoit Scherrer, Sanjay P. Prabhu, Joseph Madsen, David Fortin, Kevin Whittingstall, Maxime Descoteaux, Simon K. Warfield
2016 Human Brain Mapping  
Streamline tractography algorithms infer connectivity from diffusion MRI (dMRI) by following diffusion directions which are similarly aligned between neighbouring voxels. However, not all white matter (WM) fascicles are organized in this manner. For example, Meyer's loop is a highly curved portion of the optic radiation (OR) that exhibits a narrow turn, kissing and crossing pathways, and changes in fascicle dispersion. From a neurosurgical perspective, damage to Meyer's loop carries a potential
more » ... risk of inducing vision deficits to the patient, especially during temporal lobe resection surgery. To prevent such impairment, achieving an accurate delineation of Meyer's loop with tractography is thus of utmost importance. However, current algorithms tend to under-estimate the full extent of Meyer's loop, mainly attributed to the aforementioned rule for connectivity which requires a direction to be chosen across a field of orientations. In this article, we demonstrate that MAGNEtic Tractography (MAGNET) can benefit Meyer's loop delineation by incorporating anatomical knowledge of the expected fiber orientation to overcome local ambiguities. We propose a new ROI-mechanism which supplies additional information to streamline reconstruction algorithms by the means of oriented priors. Our results show that MAGNET can accurately generate Meyer's loop in all of our 15 child subjects (8 males; mean age This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy 10.2 years ± 3.1). It effectively improved streamline coverage when compared with deterministic tractography, and significantly reduced the distance between the anterior-most portion of Meyer's loop and the temporal pole by 16.7 mm on average, a crucial landmark used for preoperative planning of temporal lobe surgery.
doi:10.1002/hbm.23399 pmid:27647682 pmcid:PMC5333642 fatcat:7wclydvckveu5mtq5ldjem3gm4