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QSAR Study and Determination of More Potent Peptidic HIV-1-Protease Inhibitors
2017
unpublished
QSAR study of three sets of peptidic HIV-protease inhibitors has been studied. The descriptor used for study is log P. For QSAR modeling, log P has been calculated using the atom-typing scheme of Ghose and Crippen associated with CAChe. From the structure activity relationship discussion it is clear that log P is an important parameter for QSAR study. Compounds-16, 18, 19, 20, 21, 22, 24, 25, 27, 29 and 30 have high inhibitory activity greater than 9.2 but their log P value is more than 5.0
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