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A novel retinoid binding property of human annexin A6
2006
FEBS Letters
Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol. In addition, both retinoids stimulated the calcium-dependent binding of AnxA6 to liposomes, accompanied by oligomerization of AnxA6. Up to our knowledge, it is a first report supporting the
doi:10.1016/j.febslet.2006.04.052
pmid:16674946
fatcat:qdnpxnkzhjcbjg5pqbkz7tcy64