A novel retinoid binding property of human annexin A6

Marcin Balcerzak, Joanna Bandorowicz-Pikula, Rene Buchet, Slawomir Pikula
2006 FEBS Letters  
Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol. In addition, both retinoids stimulated the calcium-dependent binding of AnxA6 to liposomes, accompanied by oligomerization of AnxA6. Up to our knowledge, it is a first report supporting the
more » ... is of a direct implication of AnxA6 in vitamin A-dependent tissue mineralization.
doi:10.1016/j.febslet.2006.04.052 pmid:16674946 fatcat:qdnpxnkzhjcbjg5pqbkz7tcy64