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Ortholog detection is essential in functional annotation of genomes, with applications to phylogenetic tree construction, prediction of protein-protein interaction and other bioinformatics tasks. We present here the PHOG web server employing a novel algorithm to identify orthologs based on phylogenetic analysis. Results on a benchmark dataset from the TreeFam-A manually curated orthology database show that PHOG provides a combination of high recall and precision competitive with both InParanoiddoi:10.1093/nar/gkp373 pmid:19435885 pmcid:PMC2703887 fatcat:3y57ur55lvh3ffulsy3xnm4rei