Quantitative deciphering of local mutation in protein structures of human olfactory receptors
Fractal Geometry and Nonlinear Analysis in Medicine and Biology
In Human, Odors are detected by a large family of Olfactory Receptors (ORs) proteins. A sequence of Human ORs database has been proposed by D. Lancet et al. (2000Lancet et al. ( , 2006 based on divergence of evolutionary model. In our earlier work, we have reckoned many important features (viz. Fractal dimension of Indicator matrix, DNA walk, Hurst exponent of 2-adic and 4-adic representations, codon compositions) of DNA sequences and their corresponding amino acid sequences of human ORs and
... of human ORs and also after making local changes we have calculated the same and found significant quantitative variations between the original and edited sequences. But it is a fact that two same sequences may function different and two different sequences may function same due their specific protein structure. So for complete understanding the effect of mutation we need to study the structure of proteins of those DNA sequences. In this article, an effort has been made to understand the effect of local mutations in the amino acid sequences as well as their tertiary protein structures of Human ORs. The significant changes are resulted through the present analysis through Fractals and standard Bioinformatics tools.