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Using mice, we examined whether the topical application of tacrolimus would produce an acute anti-pruritic effect. An itch-related response, scratching, was elicited by intradermal injections of mosquito allergen (10 m mg/site) in sensitized mice and SLIGRL-NH 2 (protease-activated receptor-2 agonist, 50 nmol/site), histamine (100 nmol/site), serotonin (100 nmol/site) and substance P (100 nmol/site) in naive ones. Topical application of 1%, but neither 0.1% nor 0.3%, tacrolimus to the skin 1 hdoi:10.1248/bpb.31.752 pmid:18379077 fatcat:edolaaddjbdgvctceeo5qyk4sa